A renin inhibitor (IC50 = 0.47 nM for the recombinant human enzyme); selective for renin over β-secretase

VTP-27999 (trifluoroacetate salt) – 10 mg

Brand:
Cayman
CAS:
1013937-63-7
Storage:
-20
UN-No:
Non-Hazardous - /

VTP-27999 is a renin inhibitor (IC50 = 0.47 nM for the recombinant human enzyme).{53713} It is selective for renin over the aspartyl proteases β-secretase, cathepsin D, and cathepsin E at 10 µM and is greater than 1,000-fold selective for renin over a panel of more than 250 receptors, ion channels, and enzymes. VTP-27999 (10 mg/kg, p.o.) reduces mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension.  

 

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SKU: 27689 - 10 mg Category:

Description

A renin inhibitor (IC50 = 0.47 nM for the recombinant human enzyme); selective for renin over β-secretase, cathepsin D, and cathepsin E at 10 µM; >1,000-fold selective for renin over a panel of >250 receptors, ion channels, and enzymes; reduces mean arterial pressure in a double-transgenic rat model of angiotensin II-dependent hypertension at 10 mg/kg

Formal name: N-[2-[(R)-(3-chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-carbamic acid, methyl ester, trifluoroacetate salt

Synonyms: 

Molecular weight: 639.1

CAS: 1013937-63-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease

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