Description
A potent and selective inhibitor of Vps34 (IC50 = 25 nM in vitro); dose-dependently inhibits generation of PtdIns-(3)-p, which is essential to the formation and trafficking of endsomes and autophagosomes, without affecting the ability of class I PI3K to regulate Akt; induces a rapid and pronounced loss of phosphorylation on serum- and glucocorticoid-regulated kinase 3,
Formal name: 1-[[2-[(2-chloro-4-pyridinyl)amino]-4′-(cyclopropylmethyl)[4,5′-bipyrimidin]-2′-yl]amino]-2-methyl-2-propanol
Synonyms: Vacuolar Protein Sorting 34 Inhibitor 1|Vps34 Inhibitor 1
Molecular weight: 425.9
CAS: 1383716-33-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy
