An RSV inhibitor that demonstrates antiviral activity with an EC50 value of 1.4 nM; interferes directly with RSV fusion (EC50 = 5.4 nM)

VP-14637 – 1 mg

Brand:
Cayman
CAS:
235106-62-4
Storage:
-20
UN-No:
Non-Hazardous - /

Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein, which mediates fusion of the viral envelope with the host cell membrane, has become a target of anti-RSV treatment. VP-14637 is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM.{28943,28944} It interferes directly with RSV fusion (EC50 = 5.4 nM), binding to the viral F protein, which allows simultaneous interaction with both of the heptad repeat domains of the F protein trimer.{28943,28944}  

 

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Description

An RSV inhibitor that demonstrates antiviral activity with an EC50 value of 1.4 nM; interferes directly with RSV fusion (EC50 = 5.4 nM), binding to the viral F protein,,

Formal name: 2,2’-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-phenol

Synonyms: 

Molecular weight: 510.5

CAS: 235106-62-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|RSV Infections

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