A topoisomerase II inhibitor; induces relaxation of supercoiled DNA (IC50 = 3.2 µg/ml); induces DNA double-strand breaks in CCRF-CEM cells and cell cycle arrest at the G2 phase in A549 cells in a concentration-dependent manner; inhibits proliferation in a panel of 15 cancer cell lines

Vosaroxin – 5 mg

Brand:
Cayman
CAS:
175414-77-4
Storage:
-20
UN-No:
Non-Hazardous - /

Vosaroxin is an inhibitor of topoisomerase II.{58000} It induces relaxation of supercoiled DNA with an IC50 value of 3.2 µg/ml in a cell-free assay. It induces DNA double-strand breaks in CCRF-CEM cells and cell cycle arrest at the G2 phase in A549 cells in a concentration-dependent manner.{58001} Vosaroxin inhibits proliferation in a panel of 15 cancer cell lines, including cancer cells resistant to doxorubicin (Item No. 15007), etoposide (Item No. 12092), or cisplatin (Item No. 13119), with IC50 values ranging from 0.04 to 1.15 µM.{58002} It inhibits tumor growth in multidrug-resistant SBC-3/ETP or PC-14/CDDP mouse xenograft models when administered at a dose of 20 mg/kg.  

 

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Description

A topoisomerase II inhibitor; induces relaxation of supercoiled DNA (IC50 = 3.2 µg/ml); induces DNA double-strand breaks in CCRF-CEM cells and cell cycle arrest at the G2 phase in A549 cells in a concentration-dependent manner; inhibits proliferation in a panel of 15 cancer cell lines, including cancer cells resistant to doxorubicin, etoposide, or cisplatin (IC50s = 0.04-1.15 µM); inhibits tumor growth in multidrug-resistant SBC-3/ETP or PC-14/CDDP mouse xenograft models at 20 mg/kg

Formal name: 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid

Synonyms:  SNS-595|Voreloxin

Molecular weight: 401.4

CAS: 175414-77-4

Purity: ≥98%

Formulation: A crystalline solid

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