Description
A pan-CDK inhibitor (Kis = 0.626-9.1 nM); selective for CDKs over MAK and ICK (Kis = 259 and 481 nM, respectively), in a panel of 48 kinases; decreases Mcl-1 levels and increased cleaved PARP levels in six DLBCL cell lines at 0.5-5 µM; reduces tumor growth by 56.3% in a Ri-1 mouse xenograft model at 200 mg/kg
Formal name: 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one
Synonyms:
Molecular weight: 469.8
CAS: 1000023-04-0
Purity: ≥98%
Formulation: A crystalline solid
