A pan-CDK inhibitor (Kis = 0.626-9.1 nM); selective for CDKs over MAK and ICK (Kis = 259 and 481 nM

Voruciclib – 1 mg

Brand:
Cayman
CAS:
1000023-04-0
Storage:
-20
UN-No:
Non-Hazardous - /

Voruciclib is a pan-inhibitor of cyclin-dependent kinases (CDKs; Kis = 0.626-9.1 nM).{47780} It is selective for CDKs over male germ cell associated kinase (MAK) and intestinal cell kinase (ICK; Kis = 259 and 481 nM, respectively), in a panel of 48 kinases. Voruciclib decreases myeloid cell leukemia-1 (Mcl-1) levels and increases cleaved poly(ADP-ribose) polymerase (PARP) levels in six diffuse large B-cell lymphoma (DLBCL) cell lines when used at concentrations ranging from 0.5 to 5 µM. It reduces tumor growth by 56.3% in a Ri-1 mouse xenograft model when administered at a dose of 200 mg/kg.  

 

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SKU: 29085 - 1 mg Category:

Description

A pan-CDK inhibitor (Kis = 0.626-9.1 nM); selective for CDKs over MAK and ICK (Kis = 259 and 481 nM, respectively), in a panel of 48 kinases; decreases Mcl-1 levels and increased cleaved PARP levels in six DLBCL cell lines at 0.5-5 µM; reduces tumor growth by 56.3% in a Ri-1 mouse xenograft model at 200 mg/kg

Formal name: 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 469.8

CAS: 1000023-04-0

Purity: ≥98%

Formulation: A crystalline solid

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