A triazole antifungal agent; active against a variety of yeast and fungi (MICs = C. albicans (MICs = 0.015-8 µg/ml); inhibits ergosterol biosynthesis in C. albicans

Voriconazole – 25 mg

Brand:
Cayman
CAS:
137234-62-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Voriconazole is a triazole antifungal agent and a derivative of fluconazole (Item No. 11594).{48762,48763} It is active against a variety of yeast and fungi, including clinical isolates of A. flavus, A. fumigatus, F. oxysporum, F. solani, C. albicans, and C. neoformans (MICs = C. albicans (MICs = 0.015-8 µg/ml).{48763} It inhibits ergosterol biosynthesis in C. albicans, C. glabrata, A. fumigatus, and A. flavus (IC50s = 0.03-1 µg/ml).{24400} Voriconazole (10 mg/kg twice per day, i.v.) decreases the number of lung colony-forming units (CFUs), reduces alveolar collapse and lung inflammatory cell infiltration and necrosis, and increases survival in a rat model of invasive pulmonary aspergillosis.{48764} Formulations containing voriconazole have been used in the treatment of fungal infections.  

 

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Description

A triazole antifungal agent; active against a variety of yeast and fungi (MICs = C. albicans (MICs = 0.015-8 µg/ml); inhibits ergosterol biosynthesis in C. albicans, C. glabrata, A. fumigatus, and A. flavus (IC50s = 0.03-1 µg/ml); decreases the number of lung CFUs, reduces alveolar collapse and lung inflammatory cell infiltration and necrosis, and increases survival in a rat model of invasive pulmonary aspergillosis at 10 mg/kg twice per day, i.v.

Formal name: (αR)-α-(2,4-difluorophenyl)-5-fluoro-βS-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

Synonyms:  DRG 0301|UK 109496|VRC

Molecular weight: 349.3

CAS: 137234-62-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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