An inhibitor of mutant IDH (IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q

Vorasidenib – 1 mg

Brand:
Cayman
CAS:
1644545-52-7
Storage:
-20
UN-No:
Non-Hazardous - /

Vorsidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively).{45449} It also inhibits wild-type-IDH1R132H and wild-type-IDH2R140Q heterodimers (IC50s = 4 and 251 nM, respectively).{45451} Vorsidenib decreases the production of D-2-hydroxyglutarate (2-HG; Item Nos. 25895 | 11605) in TF-1 leukemia cells expressing IDH1R132H or IDH2R140Q (IC50s = 3.2 and 14 nM, respectively). It reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.{45450}  

 

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SKU: 28462 - 1 mg Category:

Description

An inhibitor of mutant IDH (IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively); inhibits wild-type-IDH1R132H and wild-type-IDH2R140Q heterodimers (IC50s = 4 and 251 nM, respectively); decreases the production of 2-HG in TF-1 leukemia cells expressing IDH1R132H or IDH2R140Q (IC50s = 3.2 and 14 nM, respectively); reduces tumor growth in a TS603-IDH1R132H mouse xenograft model at 50 mg/kg

Formal name: 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R )-2,2,2-trifluoro-1-methylethyl]-1,3,5-triazine-2,4-diamine

Synonyms:  AG-881

Molecular weight: 414.7

CAS: 1644545-52-7

Purity: ≥98%

Formulation: A crystalline solid

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