A potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM); weakly binds 5-HT2C

Volinanserin – 1 mg

Brand:
Cayman
CAS:
139290-65-6
Storage:
-20
UN-No:
Non-Hazardous - /

Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM).{25877,25875} It weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters.{25875,25876} Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.{25877,25878,23022}  

 

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Description

A potent and selective antagonist of the serotonin receptor 5-HT2A (Ki = 0.36-0.85 nM); weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters

Formal name: αR-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

Synonyms:  MDL 100907

Molecular weight: 373.5

CAS: 139290-65-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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