An α-glucosidase inhibitor (IC50 = 5.6 µM) that delays the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase

Voglibose – 500 mg

Brand:
Cayman
CAS:
83480-29-9
Storage:
-20
UN-No:
Non-Hazardous - /

Voglibose is a competitive α-glucosidase inhibitor (IC50 = 5.6 µM) that was first isolated from S. hygroscopicus.{31636,22626} It has been shown to delay the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase, isomaltase, and sucrase with IC50 values of 0.18, 5.2, and 0.37 µM, respectively.{22626,22628} Voglibose is also reported to increase glucagon-like peptide 1 release.{31637,31638} In clinical trials, voglibose has been used to inhibit postprandial hyperglycemia associated with diabetes without cardiovascular complications.{31636,22629}  

 

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Description

An α-glucosidase inhibitor (IC50 = 5.6 µM) that delays the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase, isomaltase, and sucrase (IC50s = 0.18, 5.2, and 0.37 µM, respectively)

Formal name: 3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-(hydroxymethyl)-D-epi-inositol

Synonyms:  AO-128

Molecular weight: 267.3

CAS: 83480-29-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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