An indole alkaloid with diverse activities; inhibits the growth of M. tuberculosis

Voacangine – 5 mg

Brand:
Cayman
CAS:
510-22-5
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Voacangine is an indole alkaloid that has been found in T. citrifolia, V. africana, V. obtusa, and T. iboga with diverse biological activities.{41758,41754} It inhibits the growth of M. tuberculosis, M. avium, and M. kansasii with MIC values of 50, >200, and 100 μg/mL, respectively.{41754} Voacangine (0.01-100 μM) dose-dependently reduces membrane currents in HEK293 cells expressing the hERG potassium channel and displaces the hERG ligand dofetilide (Item No. 15045) with a Ki value of 3.9 μM.{41755} Voacangine suppresses agonist-induced activation of transient receptor potential (TRP) channels with IC50 values of 50 and 9 μM for activation induced by the TRPV1 agonist capsaicin (Item No. 92350) and the TRPM8 agonist menthol, respectively.{41756} It also activates TRPA1 channels and stimulates calcium influx (IC50 = 8 μM in HEK293 cells expressing TRPA1), an effect that is blocked by the TRPA1 blocker HC-030031 (Item No. 11923). In vivo, voacangine (2 and 4 μg per egg) inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity.{41757}  

 

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SKU: 24692 - 5 mg Category:

Description

An indole alkaloid with diverse activities; inhibits the growth of M. tuberculosis, M. avium, and M. kansasii (MICs = 50, >200, and 100 μg/mL, respectively); dose-dependently reduces membrane current of HEK293 cells expressing hERG at 0.01-100 μM; displaces the hERG ligand dofetilide (Ki = 3.9 μM); suppresses agonist-stimulated activation of TRPV1 and TRPM8 (IC50s = 50 and 9 μM, respectively); activates TRPA1 and stimulates calcium influx (IC50 = 8 μM); inhibits angiogenesis in chick embryo chorioallantoic membranes without apparent cytotoxicity at 2 and 4 μg per egg

Formal name: 12-methoxy-ibogamine-18-carboxylic acid, methyl ester

Synonyms:  10-methoxy Coronaridine

Molecular weight: 368.5

CAS: 510-22-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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