A specific inhibitor of PTEN (IC50 = 35 nM in vitro); increases cellular PIP3 levels

VO-OHpic (hydrate) – 10 mg

Brand:
Cayman
CAS:
476310-60-8
Storage:
-20
UN-No:
Non-Hazardous - /

VO-OHpic is a specific inhibitor of phosphatase and tensin homolog (PTEN; IC50 = 35 nM in vitro).{14756,33941} Through this action, it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes.{14756} In mice, VO-OHpic (10 µg/kg, i.p.) decreases left ventricular systolic pressure and heart rate and protects against ischemia/reperfusion-induced myocardial infarction.{33944} VO-OHpic also blocks the development of suppressor activity in regulatory T cells activated with indoleamine 2,3-dioxygenase.{33942}  

 

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SKU: 10009965 - 10 mg Category:

Description

A specific inhibitor of PTEN (IC50 = 35 nM in vitro); increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes,

Formal name: (OC-6-45)-aqua(3-hydroxy-2-pyridinecarboxylato-κN1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxo-vanadate(1-), hydrogen, trihydrate

Synonyms: 

Molecular weight: 415.2

CAS: 476310-60-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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