Shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM); induces necrosis in non-proliferating quiescent core cells in multicellular spheroids formed from HCT116 colon cancer cells; displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice

VLX600 – 10 mg

Brand:
Cayman
CAS:
327031-55-0
Storage:
-20
UN-No:
Non-Hazardous - /

VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells.{28502} It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.{28502} VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs.{28502} It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.{28502}  

 

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Description

Shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM); induces necrosis in non-proliferating quiescent core cells in multicellular spheroids formed from HCT116 colon cancer cells; displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice

Formal name: 1-(2-pyridinyl)-ethanone, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone

Synonyms: 

Molecular weight: 317.4

CAS: 327031-55-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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