An analog of vitamin K3; has antiproliferative activities in vitro; preferentially decreases proliferation of IMR-32

VK3-OCH3 – 5 mg

Brand:
Cayman
CAS:
255906-59-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

VK3-OCH3 is an analog of vitamin K3 (Item No. 15950) that that has antiproliferative activities in vitro.{39810} It preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC50s = 2.43, 1.55, 10.69, and 3.45 µM, respectively) compared with non-cancerous HUVEC and HDF cells (IC50s = 26.24 and 87.11 µM, respectively). It increases heme oxygenase-1 (HO-1) and caveolin-1 levels, induces apoptosis, and halts the cell cycle at the G2/M phase in IMR-32 cells. VK3-OCH3 also inhibits protein-tyrosine phosphorylase (PTPase) activity (IC50 = 57.2 µM in a cell-free assay), induces protein-tyrosine phosphorylation in Hep3B hepatoma cells when used at a concentration of 50 µM, and inhibits the growth of Hep3B cells (IC50 = 8.6 µM).{39811}  

 

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Description

An analog of vitamin K3; has antiproliferative activities in vitro; preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC50s = 2.43, 1.55, 10.69, and 3.45 µM, respectively) compared with non-cancerous HUVEC and HDF cells (IC50s = 26.24 and 87.11 µM, respectively); increases HO-1 and caveolin-1 levels and induces apoptosis in IMR-32 cells; inhibits PTPase activity (IC50 = 57.2 µM), induces protein-tyrosine phosphorylation in Heb3B cells at 50 µM, and inhibits growth of Hep3B cells (IC50 = 8.6 µM)

Formal name: 2-[(2-methoxyethyl)thio]-3-methyl-1,4-naphthalenedione

Synonyms:  Vitamin K3-OCH3

Molecular weight: 262.3

CAS: 255906-59-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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