A biologically inactive precursor to calcitriol converted to active metabolites in vivo; obtained from dietary sources

Vitamin D3 – 1 g

Brand:
Cayman
CAS:
67-97-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Vitamin D3 is a biologically inactive precursor to calcitriol (Item No. 71820) that is converted to active metabolites in vivo.{23284,15096} Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Item No. 14612) to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3.{19039,23286} Vitamin D3 can then be converted to 25-hydroxy vitamin D3 (Item No. 9000683) in the liver by the cytochrome P450 (CYP) isoform CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney.{15096,19039} Formulations containing vitamin D3 have been used in the treatment of osteoporosis.  

 

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SKU: 11792 - 1 g Category:

Description

A biologically inactive precursor to calcitriol converted to active metabolites in vivo; obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol to previtamin D3 by UVB radiation, followed by isomerization to vitamin D3; can be converted to 25-hydroxy vitamin D3 in the liver by CYP2R1 before being converted to calcitriol by CYP27B1 in the kidney

Formal name: 3Z-[2E-[(1R,3aS,7aR)-1S-[1R,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexanol

Synonyms:  Cholecalciferol|NSC 375571

Molecular weight: 384.6

CAS: 67-97-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Vitamins||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor

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