Description
A macrolide antibiotic; active against infectious and plant pathogenic fungi, including T. vaginalis and P. oryzae (MICs = 6.25 and 12.5 µg/ml, respectively), as well as the parasite T. foetus (MIC = 25 µg/ml); decreases plaque formation by RNA and DNA viruses (ED50 = 0.0003 µg/ml for all); active against the GUTat 3.1 strain of T. brucei brucei, but not the STIB900 strain of T. brucei rhodesiense (IC50s = 0.45 and 480 ng/ml, respectively); induces cytotoxicity in human MRC-5 cells (IC50 = 80 ng/ml)
Formal name: 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoic acid, (2R,4R,5S,6R)-2-[(1S,2R,3S)-3-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen-2-yl]-2-hydroxy-1-methylbutyl]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-4-yl ester
Synonyms: AM 2604A
Molecular weight: 886.1
CAS: 84777-85-5
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides|Fungicides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Infectious Disease|Parasitic Diseases|Trichomoniasis||Research Area|Infectious Disease|Viral Diseases
