An inhibitor of V. cholerae ToxT; it inhibits ToxT dimerization and decreases CT and TCP expression (50 μM); protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae; inhibits biofilm formation by A. baumannii by 38% under static conditions (100 μM); decreases the motility of 60% of 30 mobile A. baumannii strains; binds to V. cholerae Ace (Ka = 9 x 104 M-1; Kd = 11 µM)

Virstatin – 25 mg

Brand:
Cayman
CAS:
88909-96-0
Storage:
-20
UN-No:
Non-Hazardous - /

Virstatin is an inhibitor of the ToxT transcriptional regulator of V. cholerae, which regulates transcription of virulence factors that enable intestinal colonization.{40638} It inhibits ToxT dimerization and decreases expression of cholera toxin (CT) and toxin coregulated pilus (TCP) when used at a concentration of 50 μM but virstatin does not inhibit growth of V. cholerae at this concentration (MBCs = 600 and 1,200 μM for O395 and C6706 strains, respectively).{40638,40639} Virstatin administration protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae but not from strains that colonize via non-ToxT-dependent mechanisms. Virstatin (100 μM) inhibits biofilm formation by A. baumannii by 38% under static conditions, which is at a lower concentration than that which inhibits growth (MIC = 1.6 mM).{40640} It decreases the motility of 60% of 30 mobile A. baumannii strains. Virstatin also binds to the accessory cholera enterotoxin (Ace) from V. cholerae (Ka = 9 x 104 M-1; Kd = 11 µM).{40641}  

 

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Description

An inhibitor of V. cholerae ToxT; it inhibits ToxT dimerization and decreases CT and TCP expression (50 μM); protects infant mice (5 to 6 days old) from intestinal colonization by ToxT-dependent V. cholerae; inhibits biofilm formation by A. baumannii by 38% under static conditions (100 μM); decreases the motility of 60% of 30 mobile A. baumannii strains; binds to V. cholerae Ace (Ka = 9 x 104 M-1; Kd = 11 µM)

Formal name: 1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-butanoic acid

Synonyms: 

Molecular weight: 283.3

CAS: 88909-96-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation|Gastric Disease||Research Area|Infectious Disease|Bacterial Diseases|Cholera

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