A fungal metabolite; suppresses the expression of COX-2 and iNOS and inhibits production of nitric oxide and PGE2 in LPS-stimulated RAW 264.7 and BV2 cells; inhibits NF-κB DNA-binding activity

Viridicatol – 1 mg

Brand:
Cayman
CAS:
14484-44-7
Storage:
-20
UN-No:
Non-Hazardous - /

Viridicatol is a fungal metabolite that has been found in various Penicillium species as well as Phoma.{43044,43045} It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells.{43046} It also inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation of inhibitor of kappa B α (IκBα) in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells. Viridicatol inhibits the growth of F. graminearum in a disc assay.{43045} It also inhibits protein tyrosine phosphatase 1B (PTB1B) in vitro (IC50 = 64 μM).{43047}  

 

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SKU: 25206 - 1 mg Category:

Description

A fungal metabolite; suppresses the expression of COX-2 and iNOS and inhibits production of nitric oxide and PGE2 in LPS-stimulated RAW 264.7 and BV2 cells; inhibits NF-κB DNA-binding activity, nuclear translocation of NF-κB p65 and p50 heterodimers, and blocks degradation IκBα in the cytoplasm of LPS-stimulated RAW 264.7 and BV2 cells; inhibits the growth of F. graminearum; inhibits PTB1B in vitro (IC50 = 64 μM)

Formal name: 3-hydroxy-4-(3-hydroxyphenyl)-2(1H)-quinolinone

Synonyms: 

Molecular weight: 253.3

CAS: 14484-44-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity

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