A bacterial metabolite; active against Gram-positive bacteria

Violacein – 1 mg

Brand:
Cayman
CAS:
548-54-9
Storage:
-20
UN-No:
Non-Hazardous - /

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.{43926,43928} It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone (Item No. 10007896), a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.{43927} Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively).{43928} It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.{43926}  

 

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SKU: 27959 - 1 mg Category:

Description

A bacterial metabolite; active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively); active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC50s = 0.85 and 0.63 µM, respectively); reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection at 7.5 mg/kg; increases survival in a mouse model of lethal P. chabaudi chabaudi infection; permeabilizes the cytoplasmic membrane of bacterial cells

Formal name: (3E)-3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one

Synonyms: 

Molecular weight: 343.3

CAS: 548-54-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Quorum Sensing

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