An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition

Vinorelbine (tartrate) – 5 mg

Brand:
Cayman
CAS:
125317-39-7
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

Vinorelbine is a semi-synthetic vinca alkaloid with microtubule destabilizing activity.{24892,28232} It inhibits microtubule polymerization and blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation with an IC50 value of 1.25 nM.{33560} In in vitro and in vivo models, vinorelbine has demonstrated additive effects when combined with other antimitotic agents to reduce the proliferation of various solid tumor, lymphoma, or lung cancer cell lines.{24892}  

 

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Description

An inhibitor of microtubule polymerization that blocks mitosis at the metaphase/anaphase transition, preventing HeLa cell proliferation (IC50 = 1.25 nM)

Formal name: (2β,3β,4β,5α,12R,19α)-4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid, methyl ester, 2R,3R-dihydroxybutanedioate (1:2)

Synonyms:  KW 2307

Molecular weight: 1,079.10

CAS: 125317-39-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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