An internal standard for the quantification of vildagliptin by GC- or LC-MS

Vildagliptin-d7 – 1 mg

Brand:
Cayman
CAS:
1133208-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

Vildagliptin-d7 has 7 deuteriums. Vildagliptin-d7 is intended for use as an internal standard for the quantification of vildagliptin (Item No. 14705) by GC- or LC-MS. Vildagliptin is an inhibitor of DPP-4 (IC50 = 3.5-34 nM).{24373,24372} It also inhibits DPP-8 and DPP-9 (Ki = 810 and 95 nM, respectively) but not DPP-2 or the related fibroblast activation protein α.{24377} Through its effects on DPP-4, it blocks the degradation of several circulating peptides, including incretins (stimulators of insulin secretion) like glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.{24376,24378} Vildagliptin reduces fasting and postprandial glucose levels and decreases inflammatory and oxidative stress in diverse animal models of disease.{24375,24374}  

 

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Description

An internal standard for the quantification of vildagliptin by GC- or LC-MS

Formal name: (2S)-1-[2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]-2-pyrrolidine-2,3,3,4,4,5,5-d7-carbonitrile

Synonyms: 

Molecular weight: 310.4

CAS: 1133208-42-0

Purity: ≥99% deuterated forms (d1-d7)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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