An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM

Vilazodone (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
163521-08-2
Storage:
-20
UN-No:
Non-Hazardous - /

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively).{33581} It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.  

 

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Description

An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg

Formal name: 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide

Synonyms:  EMD 68843|SB 659746A

Molecular weight: 478

CAS: 163521-08-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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