A cell-permeant inhibitor of VHL (Kd = 90 nM by ITC); promotes the accumulation of HIF-α in a concentration- and time-dependent manner

VH298 – 10 mg

Brand:
Cayman
CAS:
2097381-85-4
Storage:
-20
UN-No:
Non-Hazardous - /

VH298 is a cell-permeant inhibitor of von Hippel-Lindau disease tumor suppressor (VHL; Kd = 90 nM by isothermal titration calorimetry).{32855} VHL is a component of the complex that polyubiquitinates hydroxylated hypoxia-inducible factor-α (HIF-α) isoforms leading to proteasomal degradation. Through its effects on VHL, VH298 promotes the accumulation of HIF-α in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes.{32855}  

 

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Description

A cell-permeant inhibitor of VHL (Kd = 90 nM by ITC); promotes the accumulation of HIF-α in a concentration- and time-dependent manner, resulting in the upregulation of HIF-target genes

Formal name: (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Synonyms: 

Molecular weight: 523.7

CAS: 2097381-85-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology

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