A tremorgenic mycotoxin that selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM

Verruculogen – 1 mg

Brand:
Cayman
CAS:
12771-72-1
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi.{25045,25044} It selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM.{20613} Verruculogen also promotes the release of excitatory neurotransmitters when injected directly into the brain of rats and, at high doses, arrests mouse mammary carcinoma cells in M phase of the cell cycle (MIC = 12.2 μM).{25047,25046}  

 

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SKU: 11351 - 1 mg Category:

Description

A tremorgenic mycotoxin that selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM

Formal name: (5R,10S,10aR)-1,10,10a,14,14aS,15bS-hexahydro-10,10a-dihydroxy-7-methoxy-2,2-dimethyl-5-(2-methyl-1-propen-1-yl)-5H,12H-3,4-dioxa-5a,11a,15a-triazacyclooct[lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione

Synonyms:  NA 209A|TR 1

Molecular weight: 511.6

CAS: 12771-72-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Neuroscience

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