An inhibitor of XPO1/CRM1 with anticancer and antiviral activities; inhibits the growth of OCI-Ly3

Verdinexor – 1 mg

Brand:
Cayman
CAS:
1392136-43-4
Storage:
-20
UN-No:
Non-Hazardous - /

Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities.{48116,48117,48118} It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively).{48116} Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of respiratory syncytial virus (RSV) M protein when used at concentrations greater than 1 μM.{48117} It reduces RSV A2 replication (IC50 = 0.96 μM) without affecting viability of A549 cells (CC50 = >38 μM). In vivo, verdinexor (20 mg/kg) reduces virus shedding, pulmonary TNF-α, IL-6, MCP-1, and IFN-γ expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection.{48118} It also reduces viral burden in a ferret model of influenza A viral infection.  

 

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SKU: 26171 - 1 mg Category:

Description

An inhibitor of XPO1/CRM1 with anticancer and antiviral activities; inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 DLBCL cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively); inhibits XPO1/CRM1-mediated nuclear transport of RSV M protein at >1 μM; reduces RSV A2 replication (IC50 = 0.96 μM) without affecting viability of A549 cells (CC50 = >38 μM); reduces virus shedding, pulmonary TNF-α, IL-6, MCP01, and IFN-γ expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection at 20 mg/kg

Formal name: (2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide

Synonyms:  KPT-335

Molecular weight: 442.3

CAS: 1392136-43-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Infectious Disease|Viral Diseases|RSV Infections

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