An analog of cyclopamine that inhibits the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM and dose dependently inhibits platelet aggregation in rabbits ex vivo; induces serotonin release and inhibits its re-uptake in the CNS

Veratramine – 10 mg

Brand:
Cayman
CAS:
60-70-8
Storage:
-20
UN-No:
Non-Hazardous - /

The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}  

 

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SKU: 11724 - 10 mg Category:

Description

An analog of cyclopamine that inhibits the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM and dose dependently inhibits platelet aggregation in rabbits ex vivo; induces serotonin release and inhibits its re-uptake in the CNS

Formal name: 5S-methyl-2S-[1S-[2,3S,4,6,6aR,11,11aS,11bR-octahydro-3R-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol

Synonyms:  NSC 17821|NSC 23880

Molecular weight: 409.6

CAS: 60-70-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Signaling|Hedgehog Signaling||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cell Biology|Cell Signaling|Hedgehog Signaling

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