An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel

VER-50589 – 500 µg

Brand:
Cayman
CAS:
747413-08-7
Storage:
-20
UN-No:
Non-Hazardous - /

The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.{16496} It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.{16496} Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.{16496} VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.{16496} Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.{17993}  

 

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Description

An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel

Formal name: 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide

Synonyms: 

Molecular weight: 388.8

CAS: 747413-08-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones

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