A macrolide antibiotic with antifungal activity; also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25

Venturicidin A – 5 mg

Brand:
Cayman
CAS:
33538-71-5
Storage:
-20
UN-No:
Non-Hazardous - /

Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces.{24920} It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants.{24920} Venturicidin A is also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells.{24919} It inhibits bacterial and mitochondrial ATP synthases.{24921,24918}  

 

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Description

A macrolide antibiotic with antifungal activity; also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells; inhibits bacterial and mitochondrial ATP synthases

Formal name: (1R,5S,6R,8R,9E,11R,15E,17R)-11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-4,21-dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one

Synonyms:  Aabomycin A1

Molecular weight: 750

CAS: 33538-71-5

Purity: ≥95%

Formulation: A lyophilisate

Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Mitochondrial Biology

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