Inhibits the kinase activities of VEGFR2 (KDR)

VEGFR Tyrosine Kinase Inhibitor II – 5 mg

Brand:
Cayman
CAS:
269390-69-4
Storage:
-20
UN-No:
Non-Hazardous - /

VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).{24344} It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).{24344} VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.{24344}  

 

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Description

Inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively); possesses antiangiogenic and antitumor properties

Formal name: N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]-benzamide

Synonyms: 

Molecular weight: 337.8

CAS: 269390-69-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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