A positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation); reduces AMPA receptor-mediated eEPSCs in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM

VCP171 – 1 mg

Brand:
Cayman
CAS:
1018830-99-3
Storage:
-20
UN-No:
Non-Hazardous - /

VCP171 is a positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation).{61017}. It reduces AMPA receptor-mediated evoked excitatory postsynaptic currents (eEPSCs) in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively).{45812}  

 

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Description

A positive allosteric modulator of adenosine A1 receptors (EC50 = 15.8 μM in a kinetic assay measuring agonist dissociation); reduces AMPA receptor-mediated eEPSCs in lamina I and lamina II neurons in a rat model of neuropathic pain (EC50s = 1.995 and 0.251 μM, respectively) to a greater extent than in sham control animals (EC50s = 2.512 and 0.631 μM, respectively)

Formal name: [2-amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenyl-methanone

Synonyms: 

Molecular weight: 347.4

CAS: 1018830-99-3

Purity: ≥98%

Formulation: A crystalline solid

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