A metabolite of α-tocotrienol that has antioxidant and ferroptosis inhibitory activity; inhibits BSO-induced decreases in cell in primary fibroblasts isolated from patients with Friedreich's ataxia or Leigh syndrome (EC50s = 24 and 30 nM

Vatiquinone – 10 mg

Brand:
Cayman
CAS:
1213269-98-7
Storage:
-20
UN-No:
- 1170 / 3

Vatiquinone is a metabolite of α-tocotrienol (Item No. 10008377) that has antioxidant and ferroptosis inhibitory activity.{56151,56152} It inhibits decreases in cell viability induced by the γ-glutamylcysteine synthetase inhibitor L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in primary fibroblasts isolated from patients with the mitochondrial diseases Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively).{56151} Vatiquinone inhibits cell death and lipid peroxidation induced by the glutathione peroxidase 4 (GPX4) inhibitor RSL3 in primary fibroblasts isolated from patients with the mitochondrial encephalopathic epilepsy disease pontocerebellar hypoplasia type 6 (PCH6; EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively).{56152}  

 

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SKU: 26819 - 10 mg Category:

Description

A metabolite of α-tocotrienol that has antioxidant and ferroptosis inhibitory activity; inhibits BSO-induced decreases in cell in primary fibroblasts isolated from patients with Friedreich’s ataxia or Leigh syndrome (EC50s = 24 and 30 nM, respectively); inhibits RSL3-induced cell death and lipid peroxidation in primary fibroblasts isolated from patients with PCH6 (EC50s = 17.3-21.8 and 33.1-57.6 nM, respectively)

Formal name: 2-[(3R,6E,10E)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione

Synonyms:  EPI 743|α-Tocotrienol quinone

Molecular weight: 440.7

CAS: 1213269-98-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Seizure Disorders||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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