An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM

Vardenafil (hydrochloride hydrate) – 50 mg

Brand:
Cayman
CAS:
330808-88-3
Storage:
-20
UN-No:
Non-Hazardous - /

Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM).{24530,24529,24568} It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.{41771} Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.{41772} Formulations containing vardenafil have been used in the treatment of erectile dysfunction.  

 

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Description

An inhibitor of PDE5 (IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM); selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively); improves erectile dysfunction in a rat model of acute arteriogenic erectile dysfunction; reduces the latency to mount and increases the frequency of mounting in mice after chronic treatment at 2 mg/kg for five weeks

Formal name: 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one, monohydrochloride trihydrate

Synonyms: 

Molecular weight: 579.1

CAS: 330808-88-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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