An internal standard for the quantification of vardenafil by GC- or LC-MS

Vardenafil-d5 – 500 µg

Brand:
Cayman
CAS:
1189685-70-8
Storage:
-20
UN-No:
Non-Hazardous - /

Vardenafil-d5 is intended for use as an internal standard for the quantification of vardenafil (Item No. 14930) by GC- or LC-MS. Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM).{24530,24529,24568} It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.{41771} Chronic vardenafil administration at a dose of 2 mg/kg for five weeks to subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.{41772} Formulations containing vardenafil have been used in the treatment of erectile dysfunction.  

 

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SKU: 25225 - 500 µg Category:

Description

An internal standard for the quantification of vardenafil by GC- or LC-MS

Formal name: 2-(2-ethoxy-5-((4-(ethyl-d5)piperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

Synonyms: 

Molecular weight: 493.6

CAS: 1189685-70-8

Purity: 99% deuterated forms (d1-d5)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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