An analog of valeric acid; inhibits class I HDACs (IC50s = ~2 mM); the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia; inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze test in the APP23 transgenic mouse model of Alzheimer's disease; has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg); induces neurotoxicity at ≥1.2 mmol/kg

Valproic Acid (sodium salt) – 50 g

Brand:
Cayman
CAS:
1069-66-5
Storage:
-20
UN-No:
Non-Hazardous - /

Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM.{17456} It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP3).{9786} In vivo, valproic acid inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer’s disease.{17458} Valproic acid has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg.{42211} Formulations containing valproic acid have been used in the treatment of bipolar disorder and various seizure disorders.  

 

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Description

An analog of valeric acid; inhibits class I HDACs (IC50s = ~2 mM); the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia; inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze test in the APP23 transgenic mouse model of Alzheimer’s disease; has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg); induces neurotoxicity at ≥1.2 mmol/kg

Formal name: 2-propyl-pentanoic acid, monosodium salt

Synonyms:  2-Propylvaleric Acid|Valproate|VPA

Molecular weight: 166.2

CAS: 1069-66-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Seizure Disorders

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