A cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes

Valinomycin – 5 mg

Brand:
Cayman
CAS:
2001-95-8
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Valinomycin is a cyclododecadepsipeptide potassium-selective ionophore antibiotic that is isolated from various strains of Streptomyces. The hydrophilic interior is the right size to accommodate the potassium ion, but not other ions, while the hydrophobic exterior allows the complex to pass through the lipid bilayer. Valinomycin induces apoptosis in several cell types, including CHO cells, by stimulating potassium efflux. Apoptotic events produced by valinomycin include phosphatidylserine membrane translocation, caspase-3 activation, and mitochondrial membrane depolarization. {14421} Due to the ion-selective nature of valinomycin, it is used in ion-selective electrodes.  

 

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SKU: 10009152 - 5 mg Category:

Description

A cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes, including CHO cells, by stimulating potassium efflux

Formal name: 3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaaza-cyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecaone

Synonyms:  NSC 122023

Molecular weight: 1,111.30

CAS: 2001-95-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Mitochondrial Biology

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