A selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM for human recombinant COX-2 and COX-1

Valdecoxib – 10 mg

Brand:
Cayman
CAS:
181695-72-7
Storage:
-20
UN-No:
Non-Hazardous - /

Valdecoxib is a selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM for human recombinant COX-2 and COX-1, respectively).{42951} It decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated human whole blood (IC50 = 0.89 µM). Valdecoxib reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively).  

 

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SKU: 10006120 - 10 mg Category:

Description

A selective inhibitor of COX-2 (IC50s = 0.005 and 140 µM for human recombinant COX-2 and COX-1, respectively); decreases LPS-induced production of PGE2 in isolated human whole blood (IC50 = 0.89 µM); reduces carrageenan-induced paw edema and adjuvant-induced arthritis in rats (ED50s = 10.2 and 0.032 mg/kg, respectively)

Formal name: 4-(5-methyl-3-phenyl-4-isoxazolyl)-benzenesulfonamide

Synonyms:  SC-65872

Molecular weight: 314.4

CAS: 181695-72-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins

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