A lichen metabolite with antioxidant

Usnic Acid – 5 g

Brand:
Cayman
CAS:
125-46-2
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Usnic acid is a lichen metabolite with antioxidant, anticancer, antifungal, antiprotozoal, and antimicrobial activities.{38108,38109,38110,38111,38112} Usnic acid (>50 mg/kg) reduces the number of indomethacin-induced gastric ulcers in rats through decreased lipid peroxidation and decreased myeloperoxidase activity.{38108} It is fungicidal against C. orthopsilosis and C. parapsilosis (IC80s = 7.8 and 15.6 μg/ml, respectively) and bactericidal against seven vancomycin-resistant E. faecalis strains (MIC = 125 μg/ml).{38109,38110} Usnic acid (25 mg/kg, injected intralesionally) reduces L. amazonensis parasite loads by 72.3% in footpads of infected mice.{38111} It also reduces growth of A2780, HeLa, MCF-7, SK-BR-3, HT-29, HCT116, HL-60, and Jurkat cancer cells in vitro (IC50s = 48.5-199 μM).{38112}  

 

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Description

A lichen metabolite with antioxidant, anticancer, antifungal, antiprotozoal, and antimicrobial activities; reduces the number of indomethacin-induced gastric ulcers in rats through decreased lipid peroxidation and decreased myeloperoxidase activity; fungicidal against C. orthopsilosis and C. parapsilosis (IC80s = 7.8 and 15.6 μg/ml, respectively); bactericidal against vancomycin-resistant E. faecalis (MIC = 125 μg/ml); reduces L. amazonensis parasite loads by 72.3% in footpads of infected mice; reduces growth of cancer cells in vitro (IC50s = 48.5-199 μM),

Formal name: 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione

Synonyms:  NSC 8517

Molecular weight: 344.3

CAS: 125-46-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Parasitic Diseases|Leishmaniasis

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