A secondary bile acid; formed via epimerization of CDCA; a metabolite of LCA in human liver microsomes; inhibits taurocholic acid uptake in HeLa cells expressing recombinant NTCP (IC50 = 3.6 μM); inhibits apoptosis induced by DCA or ethanol in primary rat hepatocytes at 50 μM; dietary administration blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats

Ursodeoxycholic Acid (sodium salt) – 5 g

Brand:
Cayman
CAS:
2898-95-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item No. 10011286).{48224,48225} UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.{48226} It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.{24182} UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes.{48227} Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.  

 

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Description

A secondary bile acid; formed via epimerization of CDCA; a metabolite of LCA in human liver microsomes; inhibits taurocholic acid uptake in HeLa cells expressing recombinant NTCP (IC50 = 3.6 μM); inhibits apoptosis induced by DCA or ethanol in primary rat hepatocytes at 50 μM; dietary administration blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats

Formal name: (3α,5β,7β)-3,7-dihydroxy-cholan-24-oic acid, monosodium salt

Synonyms:  UDCA|Ursodiol

Molecular weight: 414.6

CAS: 2898-95-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Lipid Biochemistry|Lipid Transport

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