Description
A neuropeptide hormone; selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CRF2α and mouse CRF2β (EC50s = 0.16 and 0.12 nM, respectively); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells; reduces food intake in a dose- and time-dependent manner in mice (MED = 0.3 nmol/animal); increases swimming time in a forced swim test in mice, indicating antidepressant-like activity
Formal name: L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-isoleucyl-L-methionyl-L-asparaginyl-L-leucyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-asparaginyl-L-leucyl-L-arginyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-histidyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide, 2,2,2-trifluoroacetate
Synonyms:
Molecular weight: 4,137.90
CAS: 357952-09-1
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Peptides|Peptide Hormones||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Neuroendocrinology
