An end product of purine metabolism in humans that is mainly excreted in urine and can act as a potent peroxynitrite scavenger and antioxidant; high levels of serum uric acid (>120 µg/ml) are associated with gout

Uric Acid (sodium salt) – 2 mg

Brand:
Cayman
CAS:
1198-77-2
Storage:
-20
UN-No:
Non-Hazardous - /

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.{26400} The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide.{26402} Uric acid acts as a potent peroxynitrite scavenger and antioxidant.{26400,26402,6143} However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease.{26400,18377,18381,18380,18379} Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.{26401}  

 

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Description

An end product of purine metabolism in humans that is mainly excreted in urine and can act as a potent peroxynitrite scavenger and antioxidant; high levels of serum uric acid (>120 µg/ml) are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease

Formal name: 7,9-dihydro-1H-purine-2,6,8(3H)-trione, monosodium salt

Synonyms: 

Molecular weight: 190.1

CAS: 1198-77-2

Purity:

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen

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