Description
A TAM family kinase inhibitor (IC50s = 2.9, 37, and 48 nM for Mer, Axl, and Tyro3, respectively); antiproliferative against ALL cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively); inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively); decreases tumor burden by 47.8% relative to controls in human MYC transgenic zebrafish (4 μM); delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells (10 mg/kg)
Formal name: 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
Synonyms:
Molecular weight: 396.5
CAS: 1350547-65-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling
