An inhibitor of CBX7 (Kd = 97 nM); pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7; induces a senescent-like morphology and reduces growth of PC3 cells (EC50 = 7.6 μM)

UNC3866 – 5 mg

Brand:
Cayman
CAS:
1872382-47-2
Storage:
-20
UN-No:
Non-Hazardous - /

UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM).{30607} It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.  

 

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Description

An inhibitor of CBX7 (Kd = 97 nM); pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7; induces a senescent-like morphology and reduces growth of PC3 cells (EC50 = 7.6 μM),

Formal name: N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine, methyl ester

Synonyms: 

Molecular weight: 795

CAS: 1872382-47-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Chromodomains

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