A rapamycin derivative; has immunosuppressive and anti-inflammatory effects; halts the cell cycle at the G1 phase; inhibits proliferation of human smooth muscle cells; reduces stenosis in a porcine overstretch model by 50% when administered as part of the polymer coating of a coronary stent

Umirolimus – 5 mg

Brand:
Cayman
CAS:
851536-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

Umirolimus is a semi-synthetic macrocyclic lactone and a derivative of rapamycin (Item No. 13346) that has immunosuppressive and anti-inflammatory effects.{36314} It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model, coronary stents containing umirolimus for localized delivery to the vessel wall reduced stenosis by 50% and led to less thickening of the vessel wall than a bare metal stent. Rapamycin, and likely its derivatives, binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Formulations containing umirolimus have been used in coronary stents for localized delivery to the vessel wall.  

 

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SKU: 23585 - 5 mg Category:

Description

A rapamycin derivative; has immunosuppressive and anti-inflammatory effects; halts the cell cycle at the G1 phase; inhibits proliferation of human smooth muscle cells; reduces stenosis in a porcine overstretch model by 50% when administered as part of the polymer coating of a coronary stent

Formal name: 42-O-(2-ethoxyethyl)-rapamycin

Synonyms: 

Molecular weight: 986.3

CAS: 851536-75-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis

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