A muscarinic acetylcholine receptor antagonist (Kis = 0.05-0.16 nM for M1-M5); inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM); inhibits methacholine-induced bronchoconstriction in mice (ED50 = 0.02 µg

Umeclidinium (bromide) – 50 mg

Brand:
Cayman
CAS:
869113-09-7
Storage:
-20
UN-No:
Non-Hazardous - /

Umeclidinium is an antagonist of muscarinic acetylcholine receptors (Kis = 0.05-0.16 nM for M1-M5 human recombinant receptors).{39900,39902} It inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM) and bronchoconstriction in mice when administered intranasally (ED50 = 0.02 µg).{39900,39901} Formulations containing umeclidinium have been used in the treatment of chronic obstructive pulmonary disease (COPD).  

 

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Description

A muscarinic acetylcholine receptor antagonist (Kis = 0.05-0.16 nM for M1-M5); inhibits acetylcholine-induced activation of recombinant M3 receptors in CHO cell membranes (IC50 = 50 = 10 µM); inhibits methacholine-induced bronchoconstriction in mice (ED50 = 0.02 µg, intranasal),

Formal name: 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide

Synonyms:  GSK573719

Molecular weight: 508.5

CAS: 869113-09-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema

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