A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal

Umbelliferone – 50 mg

Brand:
Cayman
CAS:
93-35-6
Storage:
-20
UN-No:
Non-Hazardous - /

Umbelliferone is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor, antioxidant, and antidepressant-like properties.{36671,36672,36673} It inhibits the growth of a variety of human cell lines, including human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells, when used at concentrations ranging from 250 to 300 µg/ml.{36671} It also reversibly inhibits the production of prostate-specific androgen in LNCaP prostate cancer cells. Umbelliferone increases the production of reactive oxygen species (ROS), depolarizes the mitochondrial membrane, and halts the cell cycle at the G0/G1 phase in KB human oral carcinoma cells.{36672} In a rat model of depression induced by chronic unpredictable mild stress, umbelliferone (15 and 30 mg/kg) decreases immobility time in the forced swim test and increases sucrose consumption in the sucrose preference test, indicating antidepressant-like activity.{36673} Umbelliferone has been used as a ratiometric pH indicator that displays an emission maxima of 460 nm when solutions with a pH of less than six or greater than eight are excited at 330 and 370 nm, respectively.{36674}  

 

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Description

A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 µg/ml; increases ROS production and halts the cell cycle in KB human oral carcinoma cells; has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg; used as a ratiometric pH indicator with ex/em = 330 and 370/460 nm at low and high pH, respectively

Formal name: 7-hydroxy-2H-1-benzopyran-2-one

Synonyms:  7-hydroxy Coumarin|NSC 19790

Molecular weight: 162.1

CAS: 93-35-6

Purity: ≥98%

Formulation: A crystalline solid

Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Cycle|G1||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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