A reversible ERK1/2 inhibitor (IC50 50 value of 180 nM

Ulixertinib (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1956366-10-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ulixertinib is a reversible ERK1/2 inhibitor that demonstrates an IC50 value of V600E mutation, it has been reported to reduce the levels of phosphorylated ERK2 and the downstream kinase RSK (IC50s = 4.1 and 0.14 μM, respectively).{31542} Ulixertinib has also been shown to inhibit A375 cell proliferation with an IC50 value of 180 nM.{31542}  

 

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Description

A reversible ERK1/2 inhibitor (IC50 50 value of 180 nM

Formal name: 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide, monohydrochloride

Synonyms:  BVD-523|VRT-752271

Molecular weight: 469.8

CAS: 1956366-10-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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