A uPA inhibitor (Ki = 10 nM); 4

UK 371804 – 5 mg

Brand:
Cayman
CAS:
256477-09-5
Storage:
-20
UN-No:
Non-Hazardous - /

UK 371804 is an inhibitor of urokinase-type plasminogen activator (uPA; Ki = 10 nM).{45664} It is 4,000- and 2,700-fold selective for uPA over tissue plasminogen activator (tPA) and plasmin, respectively. UK 371804 inhibits exogenous uPA in human chronic wound fluid (IC50 = 0.89 μM). Topical administration of UK 371804 inhibits exogenous uPA activity in a porcine excisional wound model.  

 

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SKU: 27225 - 5 mg Category:

Description

A uPA inhibitor (Ki = 10 nM); 4,000- and 2,700-fold selective for uPA over tPA and plasmin, respectively; inhibits exogenous uPA in human chronic wound fluid (IC50 = 0.89 μM); topical administration inhibits exogenous uPA activity in a porcine excisional wound model

Formal name: N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine

Synonyms: 

Molecular weight: 385.8

CAS: 256477-09-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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