A class I HDAC inhibitor (IC50s = 0.06

UF010 – 25 mg

Brand:
Cayman
CAS:
537672-41-6
Storage:
-20
UN-No:
Non-Hazardous - /

UF010 is a class I HDAC inhibitor with IC50 values of 0.06, 0.1, 0.5, and 1.5 µM for HDAC3, 2, 1, and 8, respectively.{33362} It is more than 6-fold selective for these class I HDACs over any additional HDACs.{33362} UF010 is reported to inhibit cancer cell proliferation with a mean GI50 value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines and functions by blocking the G1/S phase of the cell cycle.{33362}  

 

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Description

A class I HDAC inhibitor (IC50s = 0.06, 0.1, 0.5, and 1.5 µM for HDAC3, 2, 1, and 8, respectively); inhibits cancer cell proliferation with a mean GI50 value of 2.94 μM when screened against the NCI-60 panel of cancer cell lines

Formal name: 4-bromo-benzoic acid, 2-butylhydrazide

Synonyms: 

Molecular weight: 271.2

CAS: 537672-41-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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