An inhibitor of FASN that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells); also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus

UCM05 – 1 mg

Brand:
Cayman
CAS:
1094451-90-7
Storage:
-20
UN-No:
Non-Hazardous - /

UCM05 is an inhibitor of fatty acid synthase that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells).{30886,30889} It does not alter carnitine palmitoyltransferase 1 activity or induce weight loss in mice.{30886,30889} UCM05 can reduce cleavage of poly(ADP-ribose) polymerase, phosphorylation of HER2, Akt, and ERK1/2, and growth of established xenografts in vivo.{30887} UCM05 also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division.{30888}  

 

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Description

An inhibitor of FASN that strongly suppresses the growth of human breast cancer cell lines (IC50 = 21 µM for SK-BR-3 cells); also blocks the GTP-binding site of the cell division protein FtsZ from Bacillus, preventing bacterial division

Formal name: 3,4,5-trihydr3,​4,​5-​trihydroxy-benzoic acid 1,​1′-​(1,​3-​naphthalenediyl) ester

Synonyms:  G28UCM

Molecular weight: 464.4

CAS: 1094451-90-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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