An antagonist of GluR5 subunit-containing kainate receptors; inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM); inhibits gamma frequency oscillations in the rat basolateral amygdala and blocks kainate receptor signaling mouse medial entorhinal cortical in layer III neurons (25 and 20 µM

UBP 302 – 1 mg

Brand:
Cayman
CAS:
745055-91-8
Storage:
-20
UN-No:
Non-Hazardous - /

UBP 302 is an antagonist of glutamate receptor 5 (GluR5) subunit-containing kainate receptors that inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM).{38631} In vitro, UBP 302 inhibits gamma frequency oscillations in the rat basolateral amygdala at a concentration of 25 µM, and blocks kainate receptor signaling in layer III neurons within the mouse medial entorhinal cortex at 20 µM, abrogating the intense synaptic activity characteristic of the Up state of cortical slow oscillation.{38629,38628} In vivo, UBP 302 (250 mg/kg) significantly reduces seizure severity in a rat model of soman-induced status epilepticus.{38630}  

 

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SKU: 24309 - 1 mg Category:

Description

An antagonist of GluR5 subunit-containing kainate receptors; inhibits kainate-induced responses in isolated rat dorsal roots (Kd = 402 nM); inhibits gamma frequency oscillations in the rat basolateral amygdala and blocks kainate receptor signaling mouse medial entorhinal cortical in layer III neurons (25 and 20 µM, respectively); reduces seizure severity in a rat model of soman-induced status epilepticus (250 mg/kg),,

Formal name: αS-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

Synonyms: 

Molecular weight: 333.3

CAS: 745055-91-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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